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When a bursa becomes inflamed or irritated, it can lead to painful swelling and stiffness in the affected joint

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Inflammation-associated anorexia, prevalent gastrointestinal symptoms due to slow intestinal transit, disrupted appetite regulation, and energy expenditurelinked to overexpression of leptin, increased bound leptin, irregular ghrelin secretion, and blunted ghrelin responsescorrelate with liver disease severity and systemic inflammation, further reducing food intake quantity and frequency of spontaneous food consumption (12, 16)

In this pictorial review, we sought to focus on the link between PD and Vit B12 and holistically pinpoint the peculiarities of Vit B12 effect on the molecular, neuropathological and genetic aspects of PD and overview the phenotypic expression, both motor and non-motor, of PD in the light of Vit B12 deficiency

Barassi, A., Corsi Romanelli, M.M., Pezzilli, R., Damele, C.A.L., Vaccalluzzo, L., Goi, G., Papini, N., Colpi, G.M., Massaccesi, L